In a recent announcement, Nintendo has said that they will be coming to Comic Con with a huge line-up of games for the 3DS, Wii, and DS. They will only have a small booth on the show floor, but they have a gaming lounge set up at the Marriott Marquis & Marina at 333 W. Harbor Drive, adjacent to the San Diego Convention Center. Here is the full list of playable games.
Nintendo 3DS:
Super Mario
Mario Kart
Kid Icarus: Uprising
Star Fox 64™ 3D
The Legend of Zelda™: Ocarina of Time™ 3D
Pokédex™ 3D
METAL GEAR SOLID® Snake Eater 3D from Konami
Shinobi™ from SEGA®
Super Street Fighter® IV 3D Edition from CAPCOM
RESIDENT EVIL®: THE MERCENARIES 3D from CAPCOM
DEAD OR ALIVE® Dimensions from TECMO KOEI
Wii:
The Legend of Zelda: Skyward Sword
Kirby™ Wii
Rhythm Heaven™
Fortune Street™
Captain America™: Super Soldier™ from SEGA
Just Dance® 3 from Ubisoft®
Nintendo DS™ family of systems:
Dragon Quest Monsters: Joker™ 2
Via the Nintendo 3DS Blog.